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Periodontal Mucosal Breaks Trigger RA Disease Activity

Periodontal disease (PD) is more common in rheumatoid arthritis (RA), especially those with anti-citrullinated protein antibodies (ACPAs).  RA activity has been linked to the severity of PD and mucosal inflammation.

Which Meds are Best for Acute Low Back Pain?

EurekAlert!

Acute low back pain (LBP) is a common cause of disability. An analysis in the Journal of Orthopaedic Research examined which non-opioid drugs are best for treating this condition.

New Drug Formulations – For Patients or Profits?

Wang et al., in a JAMA Network Research Letter, recently reviewed Medicaid expenditures on adalimumab (ADA), sold under the brand name HUMIRA®. They noted that the introduction of the citrate-free formulation cost an extra $4.4B to Medicaid between 2014 and 2021.

Heavy Metals and the Risk of Arthritis

The etiology of arthritis was studied using US National Health and Nutrition Examination Survey (NHANES) data and suggested that elevated concentrations of trace elements (TE: Pb, Cd, and Cu) were associated with increased risk of arthritis.

Specific ACPAs and Autoantibodies Lead to RA-Associated ILD

A BRASS registry study shows that specific isotypes of anti-citrullinated protein antibodies (ACPAs) can be associated with incident rheumatoid arthritis-associated ILD (RA-ILD).

Half the Experts are Wrong (2.17.2023)

Dr. Jack Cush reviews the news and tries to stump the expert panel this week on the podcast.

Gingival Inflammation Parallels Saliva “Cytokine Score”

Researchers at NYU College of Dentistry have developed a single score to describe the level of cytokines in the saliva, and this score is linked with the severity of clinical gum inflammation, according to a study

New Laboratory Insights for the ANA+ Consult

A new study suggests that use of ELISA assays for CXCL-10 and IFN-α can predict which ANA+ individuals may progress to developing a systemic autoimmune rheumatic disease (SARD).

Drug Safety Differences with New Novel Therapies in RA

Safety outcomes for targeted synthetic or biological disease-modifying antirheumatic drugs (b/ts DMARDs) used to treat RA were studied using data from the Anti-Rheumatic Therapies in Sweden (ARTIS) registry, showing that these newer agents are largely similar, but still have particular differences for specific infection or other adverse event risks.

Older Lupus Patients Need Follow-Up After Hospital Discharge

MedPage Today

Medicare beneficiaries 65 and older with lupus faced dramatically higher mortality when they received no follow-up care during the month after a hospital stay, researchers found.

KNOW YOUR NUMBERS! (2.10.2023)

Dr. Jack Cush reviews the news, journal articles and the numbers, from the past week on RheumNow.com.

Without DMARDS, Shoulder Arthroplasty Increasing in Rheumatoid Arthritis

The need for total shoulder arthroplasty (TSA) in rheumatoid arthritis (RA) patients appears to depend on the use of disease modifying antirheumatic drugs (DMARDs), according to Seminars in Arthroplasty.

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