Half of US Women are Overweight during Pregnancy
Obesity is associated with adverse outcomes in pregnancy, especially with higher rates of infertility and miscarriage.
News
The Unproven Use of Stem Cell Therapy in OA of the Knee
Regenerative medicine and the use of bone marrow stromal cells (or mesenchymal stem cells - MSC) is controversial in many areas of medicine, including osteoarthritis. MSC use is at a very early stage in orthopedic research, but has been investigated in osteoarthritis of the kn
Obesity Drives Rheumatoid Arthritis
Systematic review of the literature examined whether obesity is associated with a higher risk of rheumatoid arthritis (citation source http://url.ie/z1y6) and found that obese individuals (BMI > 30) are at
TNF inhibitors in Early Axial SpA Spares NSAID Use
In a 2 year follow-up of the DESIR cohort of patients with early inflammatory back pain (627 patients), TNF inhibitor use was associated with a significantly greater decrease in the median NSAID intake (from 54.9 to 1.9 in TNFi pts versus from 41.9 to 22.3 in non-TNFi pts, p0.05).
Ustekinumab Efficacy in Psoriatic Arthritis: 2 Year SUMMIT Trial Results
615 adults with active PsA were randomized to ustekinumab (45mg group or 90mg group) or placebo with crossover at 24 weeks.
Utility of Drug Levels and Anti-Drug Antibodies When Starting TNF inhibitors
A prospective cohort of 331 patients tested for anti-adalimumab (n=160) and anti-etanercept (n-171) antibodies after initiation of their TNF inhibitor therapy.
Ustekinumab Bests TNF Inhibitors for Biologic Survival in Psoriasis
Using drug survival as a global measure of a drug's effectiveness, safety and tolerability, UK investigators used a national pharmacovigilance cohort (British Association of Dermatologists Biologic Interventions Register) to compare survival rates of the first biologic used in 3,523 biologic-naiv
FUTURE 2 Trial Shows Secukinumab to be Effective in Psoriatic Arthritis
Lancet today published the results of the phase 3, prospecitive, multinational, double-blind, randomized controlled trial of secukinumab (an anti-IL-17A monoclonal antibody) in active psoriatic arthritis.
Microscopic Polyangiitis Associated with Pulmonary Fibrosis
Microscopic polyangiitis (MPA) is one of several vasculitides that affects the lung. Its most common pulmonary complication is diffuse alveolar haemorrhage, which carries a significant morbid risk.
Fresolimumab (anti-TGF beta) Improves Systemic Sclerosis
Transforming growth factor (TGF-β) is known to have potent profibrotic activity and has been implicated in the pathogenesis of systemic sclerosis a futile condition with no effective disease modifying treatments.
Management of Digital Ulcers in Scleroderma
Currently there are no FDA-approved medications for the treatment of digital ulcerations in the United States. Digital ulcers are a common, unfortunate and difficult to manage consequence of the vascular obliteration and fibrosis that accompanies systemic sclerosis.
ACP Backs Supreme Court Decision on Obamacare
ACP has endorsed the Supreme Court ruling that the premium subsidies created by the Affordable Care Act, essential to making coverage affordable to millions, will continue to be available in states where the federal government manages their health insurance marketplaces.
