Novel Mechanisms for Rheumatoid Arthritis
The Journal of Leukocyte Biology has reported mechanisms whereby synovial CD4+ T cells producing IL-21 can contribute to the pathogenesis of RA by activating synovial fibroblasts.
News
Ophthalmic Giant Cell Arteritis and the Risk of Stroke
Chronic inflammation is a well-known risk factor for cardiovascular disease and stroke.
Rheumatoid Progression Slowing Down
Patients with early rheumatoid arthritis (RA) with onset in the modern era had significantly lower baseline and annual rates of radiographic disease progression versus those with onset before 2001, researchers in England reported.
Obesity Associated with Late-Onset Psoriatic Arthritis
A recent study reports that obesity is linked to late-onset psoriasis and psoriatic arthritis (PsA). By contrast being of normal weight may be associated with an earlier onset of the disease adn HLA-B27.
EULAR Recommendations on Reproductive Issues in Lupus and Anti-Phospholipid Syndrome
There is a significant unmet need with regard to counseling and managing SLE and APS patients who become pregnant or who may be planning for pregnancy.
Can Marijuana Reduce Opioid Dependance?
The Washington Post has reported on the variable laws, views and use of marijuana in treating pain.
Currently 1.4 million patients in 28 states use legal medical marijuana for a variety of medical conditions - chronic pain being one.
High Level Rheumatoid Responses to the GM-CSF inhibitor Mavrilimumab
Despite recent advances in treatment of rheumatoid arthritis (RA), MANY patients on existent biological therapy fail to achieve remission. Therapies with novel mechanisms of actions, great efficacy and well balanced safety profile remain an unmet need.
The RheumNow Week in Review – 24 February 2017
Dr. Jack Cush reviews highlights from the past week on RheumNow.com:
Higher Hip and Knee Replacement Revision Rates in Younger Patients
Joint arthroplasty has grown into a billion dollar industry worldwide. However, optimal timing and the success of total joint replacements in younger patient groups has not been well studied.
Sirukumab Effective in Rheumatoid Arthritis
Sirukumab is a human monoclonal antibody that selectively binds to the interleukin-6 (IL-6) and is being developed for use in rheumatoid arthritis (RA) and other inflammatory diseases.
DMARD Switching in Psoriatic Arthritis
Switching biologic disease-modifying anti-rheumatic drug (bDMARD) therapy after failure of a first bDMARD for the treatment of psoriatic arthritis (PsA) can be effective, according to a review of the literature and PsA consensus treatment recommendations.
Quarter of Patients Claim Diet Influences Their Rheumatoid Arthritis
Patients often characterize certain foods as “inflammatory” or “anti-inflammatory” as they combat their arthritis.
