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Rheumatoid Arthritis Comorbidities
Dr. Jonathan Kay reviews rheumatoid arthritis studies presented on day at EULAR 2022. Specifically, he discusses abstracts OP0132, OP0135 and OP0138.
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Increasing Secukinumab Dose in Ankylosing Spondylitis Nonresponders
Dr. Peter Nash discusses abstract OP0023 from EULAR 2022.
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DMARDS, Prednisone, Pregnancy, OH MY!
Dr. Kathryn Dao discusses abstracts POS1405, POS0696 and OP0130 presented at the EULAR 2022 meeting. Watch more videos from EULAR 2022 here: https://rheumnow.com/videos.
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Breathing New Insight into RA Interstitial Lung Disease
Dr. Jonathan Kay reviews EULAR 2022 abstracts OP0132, OP0306, and OP0307.
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EULAR 2022 - Day 4 Faculty Panel Recap
Dr. David Liew and Dr. Jack Cush discuss day 4 of EULAR 2022. LB0001, LB0002, LB0004, and LB0006.
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Getting to the Heart of JAK Inhibitors
Dr. Jonathan Kay reviews rheumatoid arthritis sessions and abstracts from day 3 at EULAR 2022. Abstracts reviewed: OP0266; OP0258; and OP0269.
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EULAR 2022 - Day 3 Faculty Panel Recap
Drs. Jack Cush, Janet Pope, Aurelie Najm and Yuz Yusof discuss highlights from Day 3 of EULAR 2022.
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Deucravacitinib at EULAR 2022
Dr. Peter Nash provides and update on the TYK2 inhibitor, Deucravacitinib with reports on: - Safety of Deucravacitinib https://bit.ly/3NtZQxe - Deucravacitinib in SLE https://bit.ly/3Mh5nG0
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Janet Pope Janetbirdope
3 years 6 months ago
#ClinicalPearl Update on @eular #rheumatoid #arthritis guidelines. Reassuringly not much of an update. Very reasonable discussion of #JAKi safety. @RheumNow Day 1 of #EULAR202 T2T, shared decision making, limit #glucocorticoids to shortest time. Change MOA or not, after failure.
Md Yuzaiful Md Yusof Yuz6Yusof
3 years 6 months ago
#POS0190 #EULAR2022 Disappointing news. Despite +ve Phase 2 RCT, Results from Phase 3 RCTs of Baricitinib in #lupus is inconclusive
💠SRI4 was met in BRAVE1 but not BRAVE2 despite identical study
💠BILAG MSK & Skin improved in BRAVE1 only
BICLA wasn’t reported @RheumNow https://t.co/IfJRYEwFY8
Aurelie Najm AurelieRheumo
3 years 6 months ago
Combined nordic registers study: 🧠 demyelinating and inflammatory neuropathies in 50000+ patients starting TNFi
📍DML SpA > RA
📍INP SpA = RA
📍ETA = Other anti TNFi
But no csDMARDs control group
OP0060 #EULAR2022 @RheumNow https://t.co/LYqUW22rMg
Janet Pope Janetbirdope
3 years 6 months ago
#Bestinclass #EULAR2022 #PsA @RheumNow #OP0027 #CVE #MACE with #Tofacitinib in #psoriatic #arthritis and #PsO with median 3 to 4 yrs Rx. 40% metabolic syndrome which is high. There was no comparison. As expected hose with ⬆️MACE risks had more outcomes. https://t.co/sTjFHsUxzi
Richard Conway RichardPAConway
3 years 6 months ago
The amazing @SuAnnYeoh1 oral presentation showing terminally differentiated T effector memory re-expressing CD45RA are associated persistent disease activity in TNF non-responders (but not other bDMARDs) ?role in driving disease @RheumNow #EULAR2022 OP0011 https://t.co/OFradjuGvo https://t.co/flpFmcvixO
Richard Conway RichardPAConway
3 years 6 months ago
Dr Fabian Proft @ProftDr present CONSUL open label RCT of effect of adding NSAIDS to TNFi on structural outcomes. Bottom line, no significant difference in mSASSS. However new syndesmophytes in 11% vs 25%. @RheumNow #EULAR2022 OP0018 https://t.co/OcYH6oKbJQ https://t.co/kxH5vUdibe
TheDaoIndex KDAO2011
3 years 6 months ago
178,000 cells from knee synovium studied to eval diff in RA vs PsA transcriptomes. With RA:
👉synov Tcells ⬆️TGFB1 express'n
👉⬆️FAP+ THY1+ synovial fibroblasts
👉receptor ligand network➡️synovial T cell & macrophage synergy
👉IL-1b & TGFb synergy #EULAR2022 OP0067 @rheumnow https://t.co/0uaFyqZqBg
Dr. John Cush RheumNow
3 years 6 months ago
RheumNow’s expanded coverage of the #EULAR2022 Annual meeting is sponsored in part by Bristol-Myers Squibb. All content is chosen by RheumNow & its Faculty.
TheDaoIndex KDAO2011
3 years 6 months ago
#Plenary OP0066. Consider Whipple Dz in pts inflammatory rheum dz Screen with PCR saliva/stool samples, confirm with duodenal bx or PCR on joint fluid. pts on doxycycline and HCQ can lead to rapid remission. @rheumnow https://t.co/VcGp8pr3dT
Richard Conway RichardPAConway
3 years 6 months ago
NORD-STAR substudy looking at anticoagulant effects. Important as RA assoc. ⬆️DVT/PE. DMARDs improve haemostatic imbalance, with bDMARDs stronger effect than csDMARD (may relate to better disease control with this) @RheumNow #EULAR2022 OP0059 https://t.co/TKwAZMOZjY https://t.co/IazrfD7z7k
Md Yuzaiful Md Yusof Yuz6Yusof
3 years 6 months ago
#POS0186 #EULAR2022 AURORA2 (Extension of original RCT to 2 years) showed:
💠#lupus nephritis patients on voclosporin maintained meaningful low uPCR and stability of eGFR at 2yrs
💠No unexpected safety signals
@RheumNow https://t.co/lnohgW7BsK
Richard Conway RichardPAConway
3 years 6 months ago
Rahman et al. Factors associated with fatigue and its improvement in trials IL23i guselkumab. Disease activity/function (34%), joints (16%), skin (12%) but 38.5% of fatigue variability remains unexplained. @RheumNow #EULAR2022 OP0025 https://t.co/C08R0IWM3S https://t.co/QnCvPwEwKS
Richard Conway RichardPAConway
3 years 6 months ago
Pedersen et al report 6-fold mortality⬆️over 10 years in RA patients with co-existent depression. Even stronger effect in younger patients (<55) @RheumNow #EULAR2022 OP0067 https://t.co/vYYTmTnstQ https://t.co/xKgMu7zaOA
Aurelie Najm AurelieRheumo
3 years 6 months ago
NORD-STAR TRIAL drug does better in ttmt naive eRA? 48wks
CDAI remission ▶️ w/ ABA and CERTO PEG vs. MTX+ GCs while TCZ not stat ▶️.
Is the difference clinically sufficient to recommend these in first intention over MTX ? not convinced 🧐
OP0058 #EULAR22
@rheumnow
Eric Dein ericdeinmd
3 years 6 months ago
#EULAR OP0067
Incident depression is critical RA co-morbidity!
🚨>6x risk of death in 10 year follow-up🚨
Depression defined as 1st filling of anti-depressants
▶️Bias likely contributes, esp including neuropathic medications such as duloxetine, but data is staggering
@RheumNow https://t.co/xpQPDLonLj
Poster Hall