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      31 systemic JIA pts: w/ systemic sxs (n=8), chronic arthritis (7), remission on meds (10) & remission off meds (6).

      Dr. John Cush RheumNow

      3 years 6 months ago
      31 systemic JIA pts: w/ systemic sxs (n=8), chronic arthritis (7), remission on meds (10) & remission off meds (6). High IL-18 levels & impaired IL-18 signaling in NK cells correlated with systemic Dz activity. High IL-18 impairs NK phosphorylation https://t.co/HlaQid7xGq https://t.co/0PbxC0pZtk
      Lit search on (Lyme) Borrelia burgdorferi sensu lato shows global Bb seroprevalence =14.5% (top 3: Central Europe 20.7%,

      Dr. John Cush RheumNow

      3 years 6 months ago
      Lit search on (Lyme) Borrelia burgdorferi sensu lato shows global Bb seroprevalence =14.5% (top 3: Central Europe 20.7%,Eastern Asia 15.9%, Western Europe 13.5%). Bb seropositivity assoc w/ ≥50 yrs, men & residence of rural area https://t.co/fvr845s5CC https://t.co/TLNumNuXnH
      Balance and falls studied in 228 #RA pts (24-85 yrs) followed x 1yr; 20% had at least one fall; risks included Age (ORâ€

      Dr. John Cush RheumNow

      3 years 6 months ago
      Balance and falls studied in 228 #RA pts (24-85 yrs) followed x 1yr; 20% had at least one fall; risks included Age (OR 1.04), HAQ (OR 1.62), low FICSIT-4 score (OR 2.38) & 1-leg standing (OR  2.14). 1-leg stand is a good screening tool https://t.co/u9v8unC0gA https://t.co/oD0sgFxiQm
      Small study 34 biologic-naive RA pts starting abatacept. Remission achieved 47.1% of early and 23.5% established RA. Rem

      Dr. John Cush RheumNow

      3 years 6 months ago
      Small study 34 biologic-naive RA pts starting abatacept. Remission achieved 47.1% of early and 23.5% established RA. Remission @ 6 mos predicted by Baseline LOWER IL-6 levels ≤ 8.4 pg/ml, (66.7%) and CD4+CD25+FoxP3+ cells ≥ 6% (83.3%) https://t.co/N93E9M4M15
      Pyoderma gangrenosum (PG) is rare, but often associated with different forms of arthritis, in particular rheumatoid arthritis and inflammatory bowel diseases. 
      There are 494K PCPs in the USA, While up to 1/3 will "refill" DMARDs, only 6-9% are confident or knowledgeable in "init

      Dr. John Cush RheumNow

      3 years 6 months ago
      There are 494K PCPs in the USA, While up to 1/3 will "refill" DMARDs, only 6-9% are confident or knowledgeable in "initiating" DMARD therapy in #RA. GIGANTIC NEED FOR PCP education in MSK & Rheum Dz https://t.co/VjgWWDt3nX https://t.co/dTRXxsrzG5
      OA Initiative Study of 1212 knee OA pts (age 63 yrs), 73% walked for exercise. Walkers had signif. less New frequent kne

      Dr. John Cush RheumNow

      3 years 6 months ago
      OA Initiative Study of 1212 knee OA pts (age 63 yrs), 73% walked for exercise. Walkers had signif. less New frequent knee pain (OR 0.6) & medial joint space narrowing (OR 0.8). Walking for exercise should be encouraged in knee OA pts. https://t.co/MLs9zutdRd
      Insurance claims analysis has shown that the use of the (CDC recommended) recombinant zoster vaccine (RZV) for prevention of herpes zoster was highly used in patients with immune-mediated inflammatory diseases and was safe, as higher rates of arthritis flares were not evident.
      Watch: Fatigue and Central Sensitization in Rheumatic Disease -

      We're sharing Philip Mease, MD presentation from the R

      Dr. John Cush RheumNow

      3 years 6 months ago
      Watch: Fatigue and Central Sensitization in Rheumatic Disease - We're sharing Philip Mease, MD presentation from the RheumNow Live 2022 meeting held in March. https://t.co/SFzsszL1aM https://t.co/DkxVPim9iU
      Learn how clinical research targeting immune pathways can help reduce the burden of #psoriaticarthritis symptoms, such a

      Dr. John Cush RheumNow

      3 years 6 months ago
      Learn how clinical research targeting immune pathways can help reduce the burden of #psoriaticarthritis symptoms, such as joint pain, stiffness, and swelling, as well as fatigue: https://t.co/ReBQVyYVka Sponsored by Janssen @JanssenUS https://t.co/fRb6kAj848
      Study of interferon (IFN) gene signature (IGS) finds IGS elevated in half of early RA pts; high IGS portends higher DAS2

      Dr. John Cush RheumNow

      3 years 6 months ago
      Study of interferon (IFN) gene signature (IGS) finds IGS elevated in half of early RA pts; high IGS portends higher DAS28, fewer EULAR good resp & higher IFN-α; the latter assoc w/ epigentic changes, more lymphoctye activation. IFN-α as a biomarker? https://t.co/BHC98OR30A https://t.co/SRE7KVaoha
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