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      Placebo Works Best in Combination

      Analysis of two large clinical trial datasets shows that placebo response rates in ra

      Dr. John Cush RheumNow

      3 years 5 months ago
      Placebo Works Best in Combination Analysis of two large clinical trial datasets shows that placebo response rates in randomised controlled trials (RCTs) of patients with rheumatoid arthritis are better when the patient continued background MTX. https://t.co/JmNGRQWv6L https://t.co/77LdcTwCvl
      New Updated GRAPPA Psoriatic Arthritis Recommendations

      The GRAPPA treatment recommendations have been updated and the 2

      Dr. John Cush RheumNow

      3 years 5 months ago
      New Updated GRAPPA Psoriatic Arthritis Recommendations The GRAPPA treatment recommendations have been updated and the 2021 evidence-based guidance is rich in treatment recommendations based on the key disease "domains." https://t.co/PkDofio1eh https://t.co/kp6UEgwonV
      Gabapentin Implicated in Overdose Deaths

      Recent FDA and MMWR warnings suggest that gabapentin was present in almost 10%

      Dr. John Cush RheumNow

      3 years 5 months ago
      Gabapentin Implicated in Overdose Deaths Recent FDA and MMWR warnings suggest that gabapentin was present in almost 10% of US overdose deaths between 2019 & 2020. The report also stated that gabapentin was the cause of the death in half of these cases. https://t.co/ilNAd7ifdZ https://t.co/5GIcySXSDZ
      No science to F/U visit scheduling. Study of 114 outpt SpA visits, 34% considered unnecessary (fewer Rx change 15 v 52%)

      Dr. John Cush RheumNow

      3 years 5 months ago
      No science to F/U visit scheduling. Study of 114 outpt SpA visits, 34% considered unnecessary (fewer Rx change 15 v 52%) & clinical actions (23 v 63%) visits) vs. "necessary" visits (predict by ASDAS ≥2.1 & PtGA ≥3 >80%). Remote monitoring role? https://t.co/J8TIQRb0LG https://t.co/TCSN0NaeC8
      Dr. Jack Cush reviews recent news, regulatory and guideline updates from the past week on RheumNow.com.  Studies on methotrexate use, COVID vaccination, Supplements and vitamins, and arthrocentesis despite anticoagulation are discussed.
      A new way of inhibiting tumor necrosis factor (TNF) for treating rheumatoid arthritis showed strong results in a phase II/III clinical trial, researchers said.
      Analysis of two large clinical trial datasets shows that placebo response rates in randomised controlled trials (RCTs) of patients with rheumatoid arthritis are better when the patient continued background methotrexate (MTX). 
      Study of contoured foot orthoses vs sham shoe insoles in 1st MTP #OA pain: 87 pts completed 12 wk trial that showed no d

      Dr. John Cush RheumNow

      3 years 5 months ago
      Study of contoured foot orthoses vs sham shoe insoles in 1st MTP #OA pain: 87 pts completed 12 wk trial that showed no differences in 1st MTP walking pain or other 2nd outcomes. Hard orthoses are no more effective than flat sham insoles https://t.co/XAFWwpSjHm https://t.co/g5J9TbG2pQ
      Study of IV CTX (n 13) vs mepolizumab (n 7)(MPZ; IL-5 inhib) in severe eosinophilic granulomatosis polyangiitis. BVAS &a

      Dr. John Cush RheumNow

      3 years 5 months ago
      Study of IV CTX (n 13) vs mepolizumab (n 7)(MPZ; IL-5 inhib) in severe eosinophilic granulomatosis polyangiitis. BVAS & EOS# equal at mo 1 & 6, but MPZ had better retention(61 vs 5%) & less AEs (29% vs 54%) https://t.co/YqfOu0X3jY https://t.co/fPBzogQFal
      Full read review of Inclusion body myositis: an untreatable, slowly progressive muscle disorder seen w/ aging; distincti

      Dr. John Cush RheumNow

      3 years 5 months ago
      Full read review of Inclusion body myositis: an untreatable, slowly progressive muscle disorder seen w/ aging; distinctive pattern of weakness involving the quadriceps and finger flexor muscles, w/ certain genetic predispositions https://t.co/BxwyTacnZF https://t.co/c4wDkX6Yi9
      Danish IBD+RA registry study of TNFi induced Psoriasis in 109k non-PSO pts (20K on TNFi). PSO risk equal betw non-TNFi &

      Dr. John Cush RheumNow

      3 years 5 months ago
      Danish IBD+RA registry study of TNFi induced Psoriasis in 109k non-PSO pts (20K on TNFi). PSO risk equal betw non-TNFi & conventional Rx. Compared to latter, TNFi increased nonpustular PSO (HR 2.12; NNH 342 PY) & pustular PSO (HR 6.5; NNH 909 PY) https://t.co/5l3qlyYoFy https://t.co/Ce4RmnfHOm
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