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      Seminal Articles on Stills disease Tues Nite Rheum Journal Club tommorrow
      Discussants: Drs. Bella Mehta, Michael Weisman

      Dr. John Cush RheumNow

      3 years 5 months ago
      Seminal Articles on Stills disease Tues Nite Rheum Journal Club tommorrow Discussants: Drs. Bella Mehta, Michael Weisman & Jack Cush 7pm EDT (4pmPDT) - The 1st articles on AOSD from Bywaters & Bujak https://t.co/yRgHlmZHhi https://t.co/ooexkgM6ga Register: https://t.co/kstge3gAcl https://t.co/XjQJi4FRmt
      Study of 50 #AOSD pts refractory to steroids (n=11), DMARDs (34) & biologics (n 30): given canakinumab 150–300 mg

      Dr. John Cush RheumNow

      3 years 5 months ago
      Study of 50 #AOSD pts refractory to steroids (n=11), DMARDs (34) & biologics (n 30): given canakinumab 150–300 mg q 4wk (47) or q8wk(3). W/ 27 mos F/U: 78% complete resp w/in 3 mos (20% partial). Steroid sparing in 1/2, Low WBC 6%, 4%SIE https://t.co/QMCLictdrL https://t.co/5hkUOBFDG0
      Myths & Misconceptions with Febrile Disorders

      Dr. Rachel Tate ( @uptotate) weighs on the myths and misconceptions w

      Dr. John Cush RheumNow

      3 years 5 months ago
      Myths & Misconceptions with Febrile Disorders Dr. Rachel Tate ( @uptotate) weighs on the myths and misconceptions with Still's disease and autoinflammatory disorders. https://t.co/z0KHbxnLjJ https://t.co/ymsXYDP5Zs
      QD Clinic - Stills (or Not); A Wife's Letter

      A letter from the wife of a hospitalized febrile patient says it all.

      But

      Dr. John Cush RheumNow

      3 years 5 months ago
      QD Clinic - Stills (or Not); A Wife's Letter A letter from the wife of a hospitalized febrile patient says it all. But, is this Still's disease or not? https://t.co/MpPbDU9ZTB https://t.co/BqpusOKKLq
      213 #SLE pts were screened for Cryoglobulinemia (2013 -2017); CG is frequent in SLE (66%), but mostly asymptomatic. Mean

      Dr. John Cush RheumNow

      3 years 5 months ago
      213 #SLE pts were screened for Cryoglobulinemia (2013 -2017); CG is frequent in SLE (66%), but mostly asymptomatic. Mean levels 40mg/L (0-228). Cryo Vasculitis in 15% w/ purpura, ulcers, digit ischemia, arthritis, GN (5%) or CNS (19%) https://t.co/R6xUJldgC2 https://t.co/mwsSTI3ztk
      Can Antimalarials be Withdrawn in Quiescent Lupus?

      Antimalaria (AM) therapy is a cornerstone to the management of syste

      Dr. John Cush RheumNow

      3 years 5 months ago
      Can Antimalarials be Withdrawn in Quiescent Lupus? Antimalaria (AM) therapy is a cornerstone to the management of systemic lupus erythematosus (SLE), yet a recent study suggests that slowly tapering AM yields a lower rate of SLE flares. https://t.co/dYJy5BOKay https://t.co/pgz694ep2G
      Still’s Disease FAQs

      What is the classic 'triad' of Still's disease? Does it affect males and females equally? What a

      Dr. John Cush RheumNow

      3 years 5 months ago
      Still’s Disease FAQs What is the classic 'triad' of Still's disease? Does it affect males and females equally? What are typical lab findings? Which drugs are effective at treating Still's, and which ones are not? What about complications? Read on... https://t.co/rsFHNPwo9Y https://t.co/AUP1GpbDaN
      Many clinicians may not have seen a case of AOSD during training, which overall leads to several delays in referrals and appropriate diagnosis for AOSD patients. AOSD is an autoinflammatory disease where innate immunity plays a primary role and is characterized by seemingly unprovoked inflammation, but without the high-titer autoantibodies or antigen specific T cells seen in autoimmune diseases.
      Ustekinumab (IL-12/23i) phase 2 study was successful in #SLE; but the phase 3 LOTUS study of 512 pts, UST was NOT superi

      Dr. John Cush RheumNow

      3 years 5 months ago
      Ustekinumab (IL-12/23i) phase 2 study was successful in #SLE; but the phase 3 LOTUS study of 512 pts, UST was NOT superior to PBO (SRI-4 44% v 56%) at 1 year. Study was halted for lack of efficacy (but no safety concerns). https://t.co/uMY5uPPabA https://t.co/nG2RO6oEJQ
      Metanalysis (48 pubs, 145 refract pts) of JAK inhibitors in myositis (DM, JDM) shows significant improvement in skin les

      Dr. John Cush RheumNow

      3 years 5 months ago
      Metanalysis (48 pubs, 145 refract pts) of JAK inhibitors in myositis (DM, JDM) shows significant improvement in skin lesions, muscle weakness, and ILD. https://t.co/cYZ1YEGBOr https://t.co/MDNTSje6a2
      10% of PsA is PsA Sine Psoriasis - how to differentiate from seroneg RA? PsA sine PsO pts have peripheral arthritis, no

      Dr. John Cush RheumNow

      3 years 5 months ago
      10% of PsA is PsA Sine Psoriasis - how to differentiate from seroneg RA? PsA sine PsO pts have peripheral arthritis, no skin dz, but may have axial sxs, +Family Hx or nail psoriasis, dactylitis, enthesitis, DIP involvement. https://t.co/2RjGU6Fw2j https://t.co/r7Dsqtksh5
      MTX + Pegloticase Combo FDA Approved

      Horizon has announced that the FDA has approved the expanded labeling of peglotica

      Dr. John Cush RheumNow

      3 years 5 months ago
      MTX + Pegloticase Combo FDA Approved Horizon has announced that the FDA has approved the expanded labeling of pegloticase (Krystexxa) injection to be co-administered with methotrexate (MTX), to improve response rates in patients with uncontrolled gout. https://t.co/D71dmMuB9B https://t.co/jonfLqQ0lj
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