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Rheumatoid Arthritis Comorbidities
Dr. Jonathan Kay reviews rheumatoid arthritis studies presented on day at EULAR 2022. Specifically, he discusses abstracts OP0132, OP0135 and OP0138.
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Increasing Secukinumab Dose in Ankylosing Spondylitis Nonresponders
Dr. Peter Nash discusses abstract OP0023 from EULAR 2022.
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DMARDS, Prednisone, Pregnancy, OH MY!
Dr. Kathryn Dao discusses abstracts POS1405, POS0696 and OP0130 presented at the EULAR 2022 meeting. Watch more videos from EULAR 2022 here: https://rheumnow.com/videos.
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Breathing New Insight into RA Interstitial Lung Disease
Dr. Jonathan Kay reviews EULAR 2022 abstracts OP0132, OP0306, and OP0307.
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EULAR 2022 - Day 4 Faculty Panel Recap
Dr. David Liew and Dr. Jack Cush discuss day 4 of EULAR 2022. LB0001, LB0002, LB0004, and LB0006.
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Getting to the Heart of JAK Inhibitors
Dr. Jonathan Kay reviews rheumatoid arthritis sessions and abstracts from day 3 at EULAR 2022. Abstracts reviewed: OP0266; OP0258; and OP0269.
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EULAR 2022 - Day 3 Faculty Panel Recap
Drs. Jack Cush, Janet Pope, Aurelie Najm and Yuz Yusof discuss highlights from Day 3 of EULAR 2022.
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Deucravacitinib at EULAR 2022
Dr. Peter Nash provides and update on the TYK2 inhibitor, Deucravacitinib with reports on: - Safety of Deucravacitinib https://bit.ly/3NtZQxe - Deucravacitinib in SLE https://bit.ly/3Mh5nG0
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Dr. John Cush RheumNow
3 years 4 months ago
Retrospective study of 99 Henoch-Schönlein purpura (HSP) pts complicated by GI bleeding (61 mild; 38 severe). Severe GIB assoc w/ sufmmer Onset, facial rash, HI D-dimer (>0.89 mg/L) & neutrophil-to-lymphocyte ratio (NLR >10.56). https://t.co/9QXEFXbRiV https://t.co/T3gX92EWQ0
Dr. John Cush RheumNow
3 years 4 months ago
Population study of 28,756 individuals shows cognitive function is linked to sleep duration. Those with low (≤4 hrs) or excessive ( ≥10 hrs) sleep showed statistically significantly cognitive decline than reference group (7 hours per night) https://t.co/SDXmItMxO3 https://t.co/wMYB1u0hDb
A cohort study of SLE patients shows that remission and low disease activity (LDA) are associated with less damage accrual over time.
Patients from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort were serially assessed with different measures of remission. Damage accrual was ascertained with the SLICC/ACR Damage Index (SDI).
Repeat serologic testing is not uncommon, but is it warranted? A retrospective study shows that repeated testing for autoantibodies to extractable nuclear antigens (ENA) rarely changes the result or adds a new diagnosis.
This study from a single, multicentre tertiary health network in Australia assessed the value of a repeat ENA in patients with an initial negative result.
Dr. John Cush RheumNow
3 years 4 months ago
Should you do sural nerve biopsy (SNB) to Dx vasculitis? Study of 91 pts undergoing SNB suggests the SNB must be off sufficient length to improve Dx yield. 40/91 (44%) showed vasculitis. +SNB assoc w/ longer SNB sample, other organ Sxs & +ANCA https://t.co/aSC9xUfRFB https://t.co/lLRnrqXKaw
Dr. John Cush RheumNow
3 years 4 months ago
US national study of shows pregnancy in inflammatory bowel disease pts has higher risks for:
- gestational diabetes (AOR)
- HTN complications (1.35)
- Pre-term births (1.41)
- Fetal growth restriction (1.27)
- Fetal death (3.21)
https://t.co/3XTrrrNmoe https://t.co/udl7dXT5IF
Dr. John Cush RheumNow
3 years 4 months ago
CDC Reviews Monkeypox - 99% men, 94% male-to-male sexual contact; less prodrome; rash (100% including genital), fever (63%), chills (59%), and lymphadenopathy (59%) https://t.co/OUQPXh0RQq
https://t.co/GWpomlj5PX https://t.co/VC6mg35J1Q
Dr. John Cush RheumNow
3 years 4 months ago
150 PsA pts assessed preferences in chosing biologics (of most to less preferred):
1 Oral over SC or IV routes
2 Avoiding severe side effects
3 Resume normal activity
4 Avoid infections
5 Improve enthesitis & 6 psoriasis
7 remission
8 Joint pain https://t.co/kE3qtTWBhH https://t.co/KKcsQqEYKf
Dr. John Cush RheumNow
3 years 4 months ago
Awards issued by ACR, EULAR, BSR Reveal Gender Gap in last 2 decades. While # awards increased (including women), absolute %female prize winners remains lower than males (among 41 total awards). ACR: only ~20% recv top gold medal or Master awards https://t.co/lI548NmeW3 https://t.co/AfRwBANLOE
Dr. John Cush RheumNow
3 years 4 months ago
More Bad Safety News for Xeljanz
Another analysis of the mandatory postmarketing safety study for tofacitinib (Xeljanz) has confirmed what most observers expected: that rates of infection with the drug in RA are higher than with TNF inhibitors.
https://t.co/5FIwRMXdbT https://t.co/8k4NU6Rh6T
Patient-reported fatigue is high in patients with psoriatic arthritis (PsA) and often goes under-recognized by physicians. Fatigue importantly impacts physical functioning, work productivity, and health related quality of life (HRQoL).
A population-based study from Ontario, Canada suggests an increased mortality risk in patients with giant cell arteritis (GCA), according to a recent report in Arthritis Care & Research.
A health administrative data study looked at 22,677 GCA patients (≥50 years of age) compared to an age matched population for mortality rates between 2000 and 2018. Standardized mortality ratios (SMRs) were estimated.
Dr. John Cush RheumNow
3 years 4 months ago
CARRA Registry study of Kids who D/C DMARDs or biologics but flared & restarted meds: the recapture rate was 55% overall (47% oligoarthritis, 69% systemic JIA. By 12 mos 67% of children achieved inactive dz - better odds w/ restarting biologics (OR 2.74) https://t.co/Psgtd0O2jO https://t.co/xsecVRJqOL
Dr. John Cush RheumNow
3 years 4 months ago
Prospective study of 189 new non-infectious anterior uveitis pts, found a high prevalence SpA (56%), 93% w/ axial SpA, few (7) w/ peripheral SpA. 74/106 were newly Dx SpA. SpA predictors: psoriasis (OR 12.5), B27+ (OR 6.3),^CRP (OR 4.8) & male (OR 2.1) https://t.co/uTLmJ2QU1A https://t.co/2rejvp3yTa
Dr. John Cush RheumNow
3 years 4 months ago
Study of diet & RA in 100 new RA & 197 controls; fish/seafood consumption assoc w/ less RA risk (OR 0.52; 0.27–0.98); but processed meat intake yielded increased RA risk (OR 3.45; CI 1.78–6.68). No significant association btw RA and red meats or poultry https://t.co/wLpHfA50mY https://t.co/p2EOLBKrwW
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