Rheumatoid Arthritis
Richard Conway RichardPAConway
3 years 6 months ago
Leng et al. Tocilizumab biosimilar BAT1806/BIIB800 vs originator in MTX-IR RA. Not surprisingly they look the same. Great to see given negative clinical impact of recent supply problems with originator. @RheumNow #EULAR2022 POS0287 https://t.co/EqwINwcm7M
David Liew drdavidliew
3 years 6 months ago
Long-term low-dose steroids for RA: can it be weaned?
Weaning after 2y of blinded add-on in RA:
either PNL 5mg/d or placebo
No substantial evidence of adrenal insufficiency
- symptoms same
- cortisol/ACTH same
It's never too late to wean the pred!
OP0270 #EULAR2022 @RheumNow https://t.co/jp2ZOlAEnb
Eric Dein ericdeinmd
3 years 6 months ago
#EULAR2022 OP0274
Hospitalization for TB and other opportunistic infxn (OI) w inflamm joint disease:
⭐️9% with RA, 6% with PsA and AS in Western Australia
⭐️Decrease overall since 1985, but recent increase
⭐️Sharp rise of mycotic infections
⭐️No PJP, likely due to ppx
@Rheumnow
Richard Conway RichardPAConway
3 years 6 months ago
Yoshimura et al. 10 year findings of TOMORROW study. Glucocorticoid use of even 2mg/day is fracture risk in RA! @RheumNow #EULAR2022 POS0631 https://t.co/c8uCdPzUiE
David Liew drdavidliew
3 years 6 months ago
RA & dementia - it's getting more damning
RA dementia risk: HR 1.25
from Korean nationwide data: RA n=138,592
this follows @MyasoedovaElena's data
RA systemic inflamm leading to dementia (AD, vascular)?
Need to understand if any DMARD protective
OP0271 #EULAR2022 @RheumNow https://t.co/4V7fOtVlnj
Eric Dein ericdeinmd
3 years 6 months ago
#EULAR2022 OP0275: RA-ILD after transplant by @AARazmjou
⭐️UIP #1 cause RA-ILD, worst prognosis - 68% of transplanted pts
⭐️UIP seen in 88% of deceased patients, 56% of living
⭐️Median survival 5.3 years
@RheumNow https://t.co/tGBQ5GBlVg
Eric Dein ericdeinmd
3 years 6 months ago
#EULAR2022 OP0273
Difficult to treat RA (D2TRA):
⭐️Lower socioeconomic treatment
⭐️RF positivity
⭐️Higher inflammatory markers
⭐️ILD
⭐️Lower proportion on MTX, better response to JAKi and RTX
@RheumNow
Dr. John Cush RheumNow
3 years 6 months ago
GLORIA trial presented by Martin Boxers. 2 yr RCT, 5mg Pred vs. PBO shows DAS28 benefit (-0.37 to -0.62) & -1.7 better X-ray (vs PBO) at 2yrs. BUT signif more harm (AE) RR 1.24; mostly infx. Is this a good trade off? Abst# OP0263 #EULAR2022 https://t.co/kBiRYxXXZe
Dr. Antoni Chan synovialjoints
3 years 6 months ago
Swedish study by Lindstrom U et al of over 3000 PsA patients matched with RA comparators showed that the length of time on MTX (PsA 4.5 and RA 4.4 years) before adding or switching to b/tsDMARD was identical in PsA (34%) and matched RA controls (33%) #EULAR2022 @RheumNow POS0073 https://t.co/Dwrz8RVMnh
Eric Dein ericdeinmd
3 years 6 months ago
#EULAR2022 OP0276: What do patients want for preventative interventions for RA?
⭐️Survey of 1st degree relatives of RA pts (at risk) vs general pop were similar
⭐️'Hypothetical' treatment profile best aligned to abatacept
@Rheumnow https://t.co/r4y7SZbjTA
Aurelie Najm AurelieRheumo
3 years 6 months ago
Survival of RA-ILD pts w/ lung 🫁 transplantation
Retrospective single centre study
*Mortality 36%
*Usual Interstitial Pneumonia worst prognosis w/ HR 7.13 (did not reach significance, small cohort)
*Survival time comparable to other lung Tx cohorts
#EULAR2022 OP0275 @RheumNow https://t.co/LslPxyXJCp
A full day at EULAR with oral and poster presentations of abstracts in the morning and a plethora of scientific (review) sessions in the afternoon. The latter covering topics like sarcoidosis, Still’s disease, fibromyalgia, back pain, sarcopenia, APS, IgG4 and imaging in vasculitis.
Dr. Rachel Tate uptoTate
3 years 6 months ago
To contrast or not to contrast (in RA hand MRI?) POS0718 from #EULAR2022 showed good correlation between contrast/non-contrast imaging in synovitis, less so in tenosynovitis however. https://t.co/xL4XcRlIog
@RheumNow https://t.co/0cTep6MHLu
EULAR Congress 2022 highlighted several posters on pregnancy, an important subject as most rheumatic diseases afflicts women during their childbearing years. I wanted to share with you the ones that caught my eye because they can potentially impact medical practice.
Poster Hall