Lupus

      Less (Glucocorticoids) is More in Lupus Nephritis
      2 years 1 month ago
      AI predict ANA specific Abs? @AliDuarteMD
      Ab#0852 #ACR23 @RheumNow
      410K pts test for ANA HEp-2 IFA (136K pos, 47K spec

      Eric Dein

      2 years 1 month ago
      AI predict ANA specific Abs? @AliDuarteMD Ab#0852 #ACR23 @RheumNow 410K pts test for ANA HEp-2 IFA (136K pos, 47K specific autoAb) AI prediction models >0.80 AUC exc for RNP, Scl70 More predictive than traidtional staining patterns (p<0.001), except centromere (similar) https://t.co/4ZvP79rEdl
      Results of this study by Dr Fava show that most urinary BMs of histological activity were⬆️at 6 & 12mos in pts w

      sheila

      2 years 1 month ago
      Results of this study by Dr Fava show that most urinary BMs of histological activity were⬆️at 6 & 12mos in pts who lost GFR at 3yrs. ☝️Some LN pts still develop renal damage despite clinical response. Is there a role for BMs in monitoring tx? #ACR23 ABST0850 @RheumNow #ACRbest https://t.co/H5G6LJ22lw
      ekg line with heart in the pulse
      The Heart of Lupus
      2 years 1 month ago
      Few people are aware of the EULAR recommendations for cardiovascular risk management in SLE published in 2022.  The recommendations had 4 overarching principles: increase awareness of elevated cardiovascular risk, need for regular cardiovascular screening, assess and manage modifiable risk factors, and patient education. During ACR 2023 Convergence, several abstracts were presented evaluating the prevalence of CV disease and exploring new
      IFN 5-gene signature to ID high IFN subsets as biomarkfor DEUC in PAISLEY P2 SLE trial
      Ab847 #ACR23 @RheumNow
      IFN 5 gene

      Eric Dein

      2 years 1 month ago
      IFN 5-gene signature to ID high IFN subsets as biomarkfor DEUC in PAISLEY P2 SLE trial Ab847 #ACR23 @RheumNow IFN 5 gene score - 78% IFN-high pt IFN high ass w SLEDAI-2K, CLASI, PGA, dsDNA, low C3/C4/lmphocyte DEUC reduc IFN 5 gene score in both grps, best clin response in IFN hi https://t.co/WpZHE5z8za
      Ab#0848 @RheumNow #ACR23
      Biomarkers to Differentiate Flare from Bacterial Ifn in SLE
      CD14 and CD64 modest increase in i

      Eric Dein

      2 years 1 month ago
      Ab#0848 @RheumNow #ACR23 Biomarkers to Differentiate Flare from Bacterial Ifn in SLE CD14 and CD64 modest increase in infections v flare, better than IL-6 and MRP8/14 One marker not enough to differentiate, but in combo w/ complements, procal, dsDNA improves composite scores https://t.co/MeMYbkMTQH
      The belimumab-rituximab combination has utility in SLE, but it comes at an incremental safety cost.

      May well be worth i

      David Liew drdavidliew

      2 years 1 month ago
      The belimumab-rituximab combination has utility in SLE, but it comes at an incremental safety cost. May well be worth it in many of our patients, but very understandable that the @US_FDA label gets further clarification #ACR23 @US_FDA session @RheumNow https://t.co/RwF2wbsrQk
      #ACR23 Abstr#0782 Triple therapy in #lupus nephritis. Propensity match data AURORA vs ALMS showed pts treated with voclo

      Md Yuzaiful Md Yusof

      2 years 1 month ago
      #ACR23 Abstr#0782 Triple therapy in #lupus nephritis. Propensity match data AURORA vs ALMS showed pts treated with voclosporin+MMF+low dose GC vs MMF+High dose GC achieved earlier reduction in UPCR & fewer AEs. Cdnt control for everything e.g. HCQ but assuring @RheumNow #ACRBest https://t.co/dmriAyQPr0
      What do you think of CAR T Rx in severe #SLE? @RheumNow @ACRheum #ACR23

      Janet Pope

      2 years 1 month ago
      What do you think of CAR T Rx in severe #SLE? @RheumNow @ACRheum #ACR23
      Ab#0596 #ACR23 @RheumNow
      R Furie on Decravacitinib in SLE
      48wk double-blind trial. PBO v DEU 3mgBID, 6 mgBID,12 mg qd
      H

      Eric Dein

      2 years 1 month ago
      Ab#0596 #ACR23 @RheumNow R Furie on Decravacitinib in SLE 48wk double-blind trial. PBO v DEU 3mgBID, 6 mgBID,12 mg qd Higher response, faster time to SRI(4), BICLA and dual response v PBO. More likely to sustain response from w32-48. https://t.co/M34d3nQmwv
      LEGACY Cohort - Rx monitoring AZA/Tacro in SLE pregnancy
      Ab#0586 #ACR23 @RheumNow
      70 pregnancie. 33% prescribed AZA, 9%

      Eric Dein

      2 years 1 month ago
      LEGACY Cohort - Rx monitoring AZA/Tacro in SLE pregnancy Ab#0586 #ACR23 @RheumNow 70 pregnancie. 33% prescribed AZA, 9% TAC AZA - 91% subtherapeutic or non-adherent More likely in non-Caucasian, on steroids, longer SLE duration, prior lupus nephritis TAC - 3/6 therapeutic levels
      Targeted OX40L (co-stimulatory APC protein w/ possible polymorphisms in SLE) study by Womba et al, found OX40L targeted

      Dr. Rachel Tate

      2 years 1 month ago
      Targeted OX40L (co-stimulatory APC protein w/ possible polymorphisms in SLE) study by Womba et al, found OX40L targeted CAR-Tregs had superior in vitro suppression of activated T cells & dendritic cells relative to Control-Tregs. #ACR23 Abs 0799 https://t.co/GgCGGIvhHF @rheumnow https://t.co/GZMEUCTooh
      Should the cost of #CAR-T stop us from considering in severe refractory #lupus? So far update of German group show remis

      Janet Pope

      2 years 1 month ago
      Should the cost of #CAR-T stop us from considering in severe refractory #lupus? So far update of German group show remission - drug free and great safety. But hold on..we need RCTs with an active control and longer f/u, but I am impressed! #ACR23 #ACRbest @ACRheum @RheumNow #784 https://t.co/mRMWLCbpCY
      #ACR23 tidbits from Sunday @ACRheum @RheumNow
      1 Less steroids better w other #Rx in #GCA, #PMR, #SLE #nephritis, #nonr

      Janet Pope

      2 years 1 month ago
      #ACR23 tidbits from Sunday @ACRheum @RheumNow 1 Less steroids better w other #Rx in #GCA, #PMR, #SLE #nephritis, #nonrenal #lupus BUT NOT in Severe GCA 2 Trend for combined immune modulators in #lupus GN or w a #CNI 3 #HCQ is better than sliced bread in #SLE aim for drug level
      Differences in #glucocorticoid dosing. In #lupus #nephritis less steroids are the same as high dose steroids. Placebo ar

      Janet Pope

      2 years 1 month ago
      Differences in #glucocorticoid dosing. In #lupus #nephritis less steroids are the same as high dose steroids. Placebo arms of pooled data from #LN #RCTs. Less is equal! #ACRbest #ACR2023 ⁦@RheumNow⁩ ⁦@ACRheum⁩ abst0781 High dose steroids tended to have lower MMF doses https://t.co/XwTlsy4xKE

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