Psoriatic arthritis
Robert B Chao, MD doctorRBC
3 years 1 month ago
BE COMPLETE study:
Bimekizumab (IL-17A and IL-17F inhibitor) efficacious in phase 3 trial for treatment of PsA. No new safety signals.
Abs#1599 @RheumNow #ACR22 https://t.co/iXj7wSRNeK
Dr. Rachel Tate uptoTate
3 years 1 month ago
Abs 1507 at #ACR22 demonstrated that even a 6-month delay in PsA dx from symptom onset contributes to worse patient-reported outcomes measures on overall quality of life. @RheumNow https://t.co/qLOwE9rImz https://t.co/nacdjz5pCy
Dr. Rachel Tate uptoTate
3 years 1 month ago
The likelihood of a patient self-reporting LDA/REM and specificity of MDA score were unaffected by which MDA criteria were met. @DrLauraCoates et al, Abs 1496 #ACR22 @RheumNow https://t.co/xH70swdZZ0 https://t.co/Wct0emTaDt
Olga Petryna DrPetryna
3 years 1 month ago
#Abs1260 #acr22 @rheumnow #acrbest Clincial&US eval 54 RA &18 PsA pts: Tenderness aasoctd w/radiographic progress in non-swollen jnts in PsA but not in RA. In tender non-swollen jnts in RA pts, baseline erosions& sonographic synovitis had significant impact on radio progression https://t.co/iqWvHiDeq8
Dr. Rachel Tate uptoTate
3 years 1 month ago
RZB is efficacious in reducing signs and symptoms of PsA in patients, regardless of patterns of joint involvement Abs 1504 #ACR @AlexisOgdie @RheumNow https://t.co/AIEJbqrqBf https://t.co/kyiocs8TmL
Dr. Rachel Tate uptoTate
3 years 1 month ago
Sonographic enthesitis is assoc'd w/ sonographic synovitis and tenosynovitis in PsA. Abs 1498 #ACR22 @RheumNow https://t.co/tssYZ55iMq https://t.co/C7Dk66rwVA
Dr. Rachel Tate uptoTate
3 years 1 month ago
Delay in AS dx appeared to be BMI-dependent in female pts and both genders n PsA dx. In contrast to AS, SEC treatment response of early- and late-diagnosed PsA pts did not differ. Abs 1497 #ACR22 @RheumNow https://t.co/LBo3XapAT4 https://t.co/uAcfeiED4F
Olga Petryna DrPetryna
3 years 1 month ago
#abs1235 #acr22 @rheumnow
articular fibroblast activation in PSO assessed by 68Ga-FAPI-04 PET-CT assoctd w/⬆️ risk of developing PsA. 10 pts assessed: 6/7 pts (85.7%)w/ 68Ga-FAPI-04 uptake at synovio-entheseal sites progressed to PsA. median PsA-free time 207 (160-240)days https://t.co/Y6EHPaDwfh
Dr. Rachel Tate uptoTate
3 years 1 month ago
PsA pts starting 1st DMARD tx, both early & late initiators experienced dz activity and PRO improvements up to 6 months post-initiation. Better response, including MDA, achieved in pts initiating DMARD tx w/in 1 yr of dx. Abs 1493 #ACRbest #ACR22 @RheumNow https://t.co/a94sZRQ3VF https://t.co/OSUEoChtFf
Patricia Harkins DrTrishHarkins
3 years 1 month ago
🌟PSA vs RA 🌟
-UK cohort
PSA associated with:
👉⬆️ duration symptoms prior 2 referral
👉⬆️ interval between GP presentation and DX
👉⬇️DMARD commencement
👉⬇️ improvement in Dx activity @ 3/12
# We need to do better
#ACR22 Abst#1613 @RheumNow
Dr. Rachel Tate uptoTate
3 years 1 month ago
There is an association between the severity of skin and joint or axial disease, both at baseline and longitudinally, in pts presenting w/in 12 months of diagnosis of PsA. Abs 1511 #ACR22 @RheumNow https://t.co/PcVn6dITqU https://t.co/qxn3LBOW8d
Robert B Chao, MD doctorRBC
3 years 1 month ago
Even a 6 month delay in PsA diagnosis can lead to worse PROs on quality of life!
Likelihood of depression increased
Pts with PsA dx in <6 months reported better outcomes
Abs#1507 @RheumNow #ACR22 https://t.co/igCiH22CWi
Dr. Rachel Tate uptoTate
3 years 1 month ago
GUS (compared to RIS) uniquely binds both CD64+ myeloid cells and IL-23. CD64+ mononuclear phagocytes are enriched in the psoriatic skin and serve as the dominant IL-23 source. Does this lead to a change in clinical response? Abs 1487 #ACR22 @RheumNow https://t.co/P512bxSxRn
Patricia Harkins DrTrishHarkins
3 years 1 month ago
‼️FAP (fibroblast activation protein)
PET-CT in PsA‼️
⚡️synovial and entheseal accum in PsA v HC
⚡️correlation of uptake with pain scores
⚡️IL-17A ⬇️ FAP, with arrest joint damage
⚡️persistent FAP - ⬆️ prog joint damage
❓new T2T in PsA❓
#ACR22 @RheumNow Abst#1602


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